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Srinivas, B.
- Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -phenyl-3-mercapto-1,2,4-Triazoles
Authors
1 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, IN
2 Talla Padmavathi College of Pharmacy, ours, Karimabad, Warangal, AP, IN
3 Procadence Institute of Pharmaceutical Sciences. Gajwel, Medak,. A.P, IN
4 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 731-734Abstract
An efficient method for synthesis of 4 substituted 5 -phenyl - 3- mercapto -1, 2, 4 -triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4- oxadiazole-2 - thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.Keywords
Triazoles, Oxadiazole, Grass Behavior Study, Locomotor Activity
References
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- Stable and pH-Responsive Core–Shell Nanoparticles Based on HEC and PMAA Networks via Template Copolymerization
Authors
1 Dr. Reddys Laboratories, Bachupally, Hyderabad, A.P., IN
2 Mother Teresa College of Pharmaceutical Sciences, NFC Nagar, Ghatkesar, IN
3 Anurag Pharmacy College, Kodad, AP, IN
4 RS I Laboratories, Hyderabad, AP, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 108-115Abstract
Taking advantage of the specific hydrogen bonding interactions, stable and pH-responsive core-shell nanoparticles based on hydroxyethyl cellulose (HEC) and polymethacrylic acid (PMAA) networks, with a (Dh ) size ranging from 190 to 250 nm, can be efficiently prepared via facile one-step co-polymerization of methacrylic acid (MAA) and N,N'- methylenebisacrylamide (MBA) on HEC template in water. Using dynamic light scattering, electrophoretic light scattering, fluorescence spectrometry, thermo-gravimetric analysis, TEM, and AFM observations, the influence of crosslinker MBA as well as the reaction parameters were studied. The results show that after the introduction of crosslinker MBA, the nanoparticles became less compact; their size exhibited a smaller pH sensitivity, and their stability against pH value was improved greatly. Furthermore, the size, structure, and pH response of the nanoparticles can be adjusted via varying the reaction parameters: nanoparticles of smaller size, more compact structure, and higher swelling capacity were produced as pH value of the reaction medium increased or the HEC/MAA ratio decreased; while nanoparticles of smaller size, less compact structure and smaller swelling capacity were produced as the total feeding concentration increased.